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Leveraging spectrally encoded beads for highly multiplexed profiling of SARS-CoV-2/host cell protein/protein and protein/peptide interactions

Why:

Rapid and low-cost diagnosis of active as well as past infection is essential for disease surveillance, but current serological tests can only detect past disease.

Project plan:

The Fordyce lab is applying a spectrally encoded bead technology they have recently developed for high-throughput and multiplexed testing of protein-peptide interactions critical for identifying SARS-CoV-2 antibodies as well as the virus itself. In collaboration with Catherine Grimes at the University of Delaware and Paramjit Arora at NYU, the Fordyce Lab is testing a variety of peptides computationally designed to be high-affinity and specific for these interactions.

Relevant publications:

Collaborators:

  • Catherine Grimes (University of Delaware)
  • Paramjit Arora (NYU)