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| Honors & Awards |
| Damon Runyon Cancer Research Foundation, Postdoctoral Fellowship, 2004-2006 |
| University of California, San Diego, First Graduate of the Bioinformatics Program, 2003 |
| Brigham Young University, Ezra Taft Benson Presidential Scholarship, 1991-1997 |
| Education |
| Ph.D., Bioengineering with specialization in Bioinformatics,University of California, San Diego, 2003 |
| B.S., Chemical Engineering, Brigham Young University, 1997 |
Research Interests Our focus is on building computational models of complex biological processes, and using these models to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors whose aberrant activity has been linked to oncogenesis, tumor progression, and resistance to chemotherapy. |
Representative Publications
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Covert, M.W., "Integrated regulatory and metabolic models", in Computational Systems Biology, Academic Press, New York, 2005. |
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Covert,
M.W.*, “Achieving Stability of Lipopolysaccharide-Induced NF-kappaB
Activation,” Science, 309:1854-1857, 2005 (* equal contribution with T.H. Leung). Highlighted in Science STKE Vol. 2005, Issue 302, pp. tw335, 20 September 2005. |
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Covert,
M.W., et al., “Integrating high-throughput experimental and computational
data elucidates bacterial networks,” Nature 429: 92-96, 2004. Alliance for Cell Signaling Featured Article, May 2004; Featured Article with interview in The Scientist 18(14):42; News and Views Research Note in Nature Biotechnology 22:686, 2004. |
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Herrgard,
M.J., et al., “Reconstruction of Microbial Transcriptional Regulatory
Networks”, Current Opinion in Biotechnology 15:70-77, 2004. |
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Covert,
M.W., et al., “Identifying the Constraints that Govern Cell Behavior,” Biotechnology and Bioengineering 84(7):763-72, December 2003. B&B’s 5th-Most Downloaded Article of the Year (11/03-10/04). |
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Herrgard,
M.J., et al., “Reconciling Gene Expression Data with Known Genome-Scale Regulatory Network Structures,” Genome Research 13(11):2423-34, November 2003. |
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Covert,
M.W. and B.O. Palsson, “Constraints-Based Models: Regulation of Gene
Expression Reduces the Steady State Solution Space,” Journal of Theoretical Biology 221(3):309-25, April 2003. |
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Covert,
M.W. and B.O. Palsson, “Transcriptional Regulation in Constraints-Based
Metabolic Models of Escherichia coli,” Journal of Biological Chemistry 277(31):28058-64, August 2002. |
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Schilling,
C.H., et al., “Genome-Scale Metabolic Model of Helicobacter pylori
26695,” Journal of Bacteriology 184(16):4582-4593, August 2002. |
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Edwards,
J.S., et al., “Metabolic Modeling of Microbes: the Flux-Balance Approach,” Environmental Microbiology 4(3):133-40, March 2002. |
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Covert,
M.W., et al., “Regulation of Gene Expression in Flux Balance Models
of Metabolism,” Journal of Theoretical Biology 213(1):73-88, November 2001. |
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Covert,
M.W., et al., “Metabolic Modeling of Microbial Strains in silico,” Trends
in the Biochemical Sciences 26(3):179-86, March 2001. |
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