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Howard Hughes Medical Institute Predoctoral Fellowship, 1999 |
| Education |
Ph.D., Molecular and Cell Biology, University of California, Berkeley, 2003 |
B.Sc., Biochemistry, University of Washington, Seattle, WA, 1998 |
| Research
Interests Molecular motors lie at the heart of biological processes from DNA replication to vesicle transport. My laboratory seeks to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work. We use single molecule tracking and manipulation techniques to observe and perturb substeps in the mechanochemical cycles of individual motors. Protein engineering helps us to explore relationships between molecular structures and mechanical functions. Broad topics of current interest include torque generation by DNA-associated ATPases and mechanical adaptations of unconventional myosins. |
Representative Publications
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Nöllmann, M., Stone, M.D., Bryant, Z., Gore, J., Crisona, N., Hong, S.-C., Mitelheiser, S., Maxwell, A., Bustamante, C., and Cozzarelli, N.R. (2007) Multiple modes of E. Coli DNA gyrase activity revealed by force and torque. Nat Struct Mol Biol [Epub March 4]. |
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Bryant, Z., Altman, D., and Spudich, J.A. (2006) The power stroke of myosin VI and the basis of reverse directionality. Proc Natl Acad Sci U S A [Epub Dec 20]. |
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Gore, J., Bryant, Z., Nöllman, M., Le, M., Cozzarelli, N.R., and Bustamante, C. (2006) DNA overwinds when stretched. Nature 442, 836-839. |
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Gore, J., Bryant, Z., Stone, M. D., Nolllman, M., Cozzarelli, N. R. and Bustamante, C. (2006). Mechanochemical analysis of DNA gyrase using rotor bead tracking. Nature 439 (7072): 100-104. |
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Bryant, Z., Stone, M. D., Gore, J., Smith, S. B., Cozzarelli, N. R. and Bustamante, C. (2003). Structural transitions and elasticity from torque measurements on DNA. Nature 424 (6946): 338-341. |
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Stone, M. D., Bryant, Z., Crisona, N. J., Smith, S. B., Cozzarelli, N. R. and Bustamante, C. (2003). Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases. PNAS 100 (15): 8654-8659. |
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Bustamante, C., Bryant, Z. and Smith, S.B. (2003). Ten years of tension: single-molecule DNA mechanics. Nature 421 (6921): 423-427. Review. |
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Parak, W. J., Gerion, D., Zanchet, D., Woerz, A. S., Pellegrino, T., Micheel, C., Williams, S. C., Seitz, M., Bruehl, R. E., Bryant, Z., Bustamante, C., Bertozzi, C.R. and Alivisatos, A.P. (2002). Conjugation of DNA to silanized colloidal semiconductor nanocrystalline quantum dots. Chemistry of Materials 14: 2113-2119. |
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Bryant, Z., Pande, V. S. and Rokhsar, D. S. (2000). Mechanical unfolding of a beta-hairpin using molecular dynamics. Biophys J 78 (2): 584-589. |
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Bryant, Z., Subrahmanyan, L., Tworoger, M., LaTray, L., Liu, C. R., Li, M. J., van den Engh, G. and Ruohola-Baker, H. (1999). Characterization of differentially expressed genes in purified Drosophila follicle cells: toward a general strategy for cell type-specific developmental analysis.PNAS 96 (10): 5559-5564. |
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Tworoger, M., Larkin, M. K., Bryant, Z. and Ruohola-Baker, H. (1999). Mosaic analysis in the drosophila ovary reveals a common hedgehog-inducible precursor stage for stalk and polar cells. Genetics 151 (2): 739-48. |
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Clegg, N. J., Frost, D. M., Larkin, M. K., Subrahmanyan, L., Bryant, Z. and Ruohola-Baker, H.(1997) maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA. Development 124: 4661-71. |
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